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Sara Abouradi

CASABLANCA University, School of Medicine, Morocco

Title: Mitral Effective Regurgitant Orifice Area and elevated Pulmonary Artery Pressure Level in Patients with Aortic Valve Stenosis in Morocco

Biography

Biography: Sara Abouradi

Abstract

INTRODUCTION: Pulmonary hypertension and mitral regurgitation are frequently associated in the context of patients with aortic stenosis , but  there are no specific quantitative studies about how much mitral regurgitation  is related to pulmonary hypertension, The purpose of the study was to investigate whether the quantification of Mitral Régurgitation reveals a link to Pulmonary hypertension H in patients with aortic stenosis.

METHODS: This is a retrospective study from February 2018 to October 2019 including all patients with Aortic stenosis admitted to the day hospital of the cardiology department. Effective regurgitant orifice area (ERO) was obtained using the proximal isovelocity surface area method. Systolic pulmonary artery pressure was calculated by adding right atrial pressure to the tricuspid regurgitation pressure gradient.

RESULTS: The mean age, was 60 ± 14 years; mean ejection fraction : 56 ± 9%; mean aortic valve area : 1.04 ± 0.45 cm2); Mitral régurgitation was present in 67,4%. the ERO was < 0.20 cm2 in 75%, between 0,20 ans 0,30 cm² in 13,3% and over 0,3cm² in 11,7%. Associations between ERO and systolic pulmonary artery pressure was statistically significant (P < .0001). This relationship persisted after multivariate adjustment and in the subgroups of patients with severe aortic stenosis  or reduced ejection fraction (P < .0001)  For each 0.10-cm2 increase, the odds ratio for hypertension pulmonary  were 1,43 (95% CI, 0,4-5) ;  2,05(95% CI,1,18-3,5) ; and 3.08 (95% CI, 2.19-6,09) respectively .

CONCLUSIONS: In this study we conclude  to a relationship between Mitral Regurgitation severity and pulmonary hypertension  in patients with aortic stenosis  , the presence of MR and its quantitative assessment could become a prognostic marker of a high-risk for  patients with aortic stenosis.  .