Cardiac Pharmacology

The advent of drugs bright to modulate the renin–angiotensin system (RAS), and more recently the neprilysin inhibitor sacubitril in mixture with a RAS blocker, has better the outcome of many cardiovascular and renal conditions. In specific, heart failure, post-myocardial infarction, and hypertension are the cardiovascular clinical syndromes in which RAS inhibition (and in heart failure, in combination with neprilysin inhibition) have significantly improved morbidity and mortality. This section aims to offer an appraisal of RAS and neprilysin inhibitors concerning their pharmacological properties with respect to mechanism(s) of action, pharmacokinetics, monitoring, adverse effects, and drug interactions.



 


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